Immunomodulatory Activities of Artocarpus incisus, Linn. F. Extract

Abstract

Immunomodulatory Activities of Artocarpus incisus, Linn. F. Extract

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Aurasorn Saraphanchotiwitthaya

Naresuan University, Thailand

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Abstract

The immunomodulatory effects of Artocarpus incisus heartwood extract on macrophage and splenocytes of ICR mouse were studied. The phagocytic activity of peritoneal macrophages and splenocyte proliferation in the absence and presence of mitogens (phytohemagglutinin, concanavalin A, lipopolysaccharide and pokeweed mitogen) were assayed. The extract effected to the enhancement of lysosomal enzyme activity but had no effect on the oxidative burst reduction on phagocytosis. Antiproliferative activity of spleen T- and B-lymphocytes was also presented. The extract with PWM gave the maximum suppression of B-lymphocyte proliferation, suggesting specificity towards T cell dependent pathway the same as PWM. These results may prove the folklore remedy of this plant relating to immune system.

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Keywords: Artocarpus incisus, ICR mouse, phagocytosis, antiproliferative activity, immune system