Immunomodulatory Activities of Artocarpus incisus, Linn. F. Extract

Abstract

The immunomodulatory effects of Artocarpus incisus heartwood extract on
macrophage and splenocytes of ICR mouse were studied. The phagocytic activity of
peritoneal macrophages and splenocyte proliferation in the absence and presence of mitogens
(phytohemagglutinin, concanavalin A, lipopolysaccharide and pokeweed mitogen) were
assayed. The extract effected to the enhancement of lysosomal enzyme activity but had no
effect on the oxidative burst reduction on phagocytosis. Antiproliferative activity of spleen
T- and B-lymphocytes was also presented. The extract with PWM gave the maximum
suppression of B-lymphocyte proliferation, suggesting specificity towards T cell dependent
pathway the same as PWM. These results may prove the folklore remedy of this plant
relating to immune system.

Keywords: ??Artocarpus incisus, ICR mouse, phagocytosis, antiproliferative activity, immunesystem